Further, Ca+/CnA/NFAT signaling pathway is linked to several nervous system diseases as Down Syndrome, Alzheimer’s, Huntington’s, traumatic brain injuries, amyotrophic lateral sclerosis, and others (Kipanyula et al. 2016; Park et al. 2009; Minami 2014; Sompol and Norris 2018) suggesting a relevant role for this transcription factor pathway in nervous system physiological maintenance and development, including Parkinson’s disease. Here, PPP3CA is linked to Down syndrome.