LZTS2 and cancer: Compared with previous studies that investigated the value of TMEscore in other cancers [10, 12, 25], our study constructed a four-gene TME signature using TMEscore-related genes (CXCL10, LZTS2, IDO1, and MAB21L2), making it easy for clinicians to assess patients who might belong to the TME-H or TME-L signature.