This study was innovative to some extent: it took the SEs as the entry point, with the purpose of discovering potential new biomarker for predicting the prognosis of breast cancer, and a prognostic model on the basis of SERGs was constructed; in addition to validating the model through testing set, the biological function of ZIC2 was also preliminarily explored in vitro experiments. This evidence concerns the gene ZIC2 and breast carcinoma.