WDR35 and cranioectodermal dysplasia: Molecular analysis showed that he carried novel compound heterozygous variants of a nonsense variant (c.2590 C > T, p.Gln864*) and a deletion variant (c.2408_2416del, p.Asn803_Ala805del) in WDR35. We describe the detailed clinical characteristics of one Chinese patient and present a novel clinical feature that might be associated with CED, which further expands the genotype-phenotype spectrum of WDR35 and provides help to early precision diagnoses and genetic counseling.