VEGFA and early-onset autosomal dominant Alzheimer disease: Tarkowski et al. evidenced higher CSF levels of VEGF in AD and VaD than controls; Blasko et al. demonstrated no difference in CSF VEGF levels between AD and controls; and data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) found lower CSF levels of VEGF capable to distinguish AD from controls with 76% sensitivity and a 84% specificity19,52,53.