Among the subgroup of APOE ε4 non-carriers, VEGF rs699947 AA and rs833061 CC genotypes were significantly associated with a decreased AD risk in the codominant model, P = 0.021 OR = 0.38 (0.17–0.86); P = 0.021 and, similarly, participants with the C allele in the SNP VEGF rs699947 or the T allele in the SNP VEGF rs833061 had higher risk to suffer from AD in our sample, P = 0.033 in recessive model, OR = 2.17 (1.06–4.42), which remained statistically significant after controlling for vascular risk factors. This evidence concerns the gene APOE and Alzheimer disease.