We selected several F-box proteins (FBXO15, FBXO17, FBXO24, FBXO28, FBXO46, FBXW8, FBXL7) whose functions are scarcely reported in EMT and metastasis of HCC, and evaluated their effect on the migration capability of Huh7 cells in a transwell assay upon gene knockdown. The gene discussed is FBXO46; the disease is hepatocellular carcinoma.