To further determine whether FBXO28-mediated SNAI2 degradation is critical for the inhibitory functions of FBXO28 in HCC migration, invasion and metastasis, we compared the biological effects of Hep3b cells stably expressing shFBXO28 alone or in combination with shSNAI2 by lentiviral infection. This evidence concerns the gene FBXO28 and hepatocellular carcinoma.