We selected several F-box proteins (FBXO15, FBXO17, FBXO24, FBXO28, FBXO46, FBXW8, FBXL7) whose functions are scarcely reported in EMT and metastasis of HCC, and evaluated their effect on the migration capability of Huh7 cells in a transwell assay upon gene knockdown. Here, FBXW8 is linked to hepatocellular carcinoma.