Moreover, the FBXO28 inhibited SNAI2 protein level was fully rescued by treatment with a proteasome inhibitor MG132 in the Huh7 cells as well as human breast cancer MDA-MB-231, lung cancer NCI-H460 and osteosarcoma Saos-2 cell lines (Fig. 3C; Supplementary Fig. S4D). The gene discussed is SNAI2; the disease is breast cancer.