Given that MYC is a target of FBXO28 in HCT116 cells [12] and inhibits metastasis as well [18], we further investigated whether MYC may be affected and detected no change of MYC protein levels by FBXO28 overexpression or knockdown in HCC cells (Supplementary Fig. S4E), excluding the possible involvement of MYC under this context. Here, MYC is linked to hepatocellular carcinoma.