Somewhat unexpectedly, miR-206 was identified as the only miRNA that can target both HMGCR or G6PD by interacting with two miR-206 binding sites within the 3’UTR of HMGCR or G6PD. Consistently, levels of HMGCR and G6PD are significantly increased in tumors of HCC patients; and a positive association was observed between HMGCR and G6PD in HCC (Supplementary Fig. 10). Here, HMGCR is linked to hepatocellular carcinoma.