Using STRING database, we identified a network of potential interactions21 for sortilin and syndecan-1 (Fig. 2a), which may be involved in PCa pathogenesis and analysed the expression of these genes in LNCaP and PC3 cells using RNA sequencing (RNAseq) (Supplementary Fig. S1 and Supplementary Table S1). The gene discussed is SDC1; the disease is posterior cortical atrophy.