Using STRING database, we identified a network of potential interactions21 for sortilin and syndecan-1 (Fig. 2a), which may be involved in PCa pathogenesis and analysed the expression of these genes in LNCaP and PC3 cells using RNA sequencing (RNAseq) (Supplementary Fig. S1 and Supplementary Table S1). Here, SORT1 is linked to posterior cortical atrophy.