IL6 and septic shock: Because cytokine levels decrease spontaneously very rapidly in the absence of a triggering signal (DAMP/PAMP)32,37 and the reduction of IL-6 in our study was observed in both our groups (adsorber and SOC), the question arises as to the appropriateness of measuring serum IL-6 as a marker of clinically relevant improvement in patients with septic shock treated with hemoadsorption.