HBEGF and neoplasm: To test whether decreased tumor cell fitness in this relevant model induces encapsulation and to achieve a stronger tumor regression than that observed after chemotherapy, we engineered KPCT cells to express the diphtheria toxin receptor (DTR)40, which murine cells lack, thereby making KPCT cells sensitive for diphtheria toxin (DT); enrichment after transfection resulted in ~90% DTR+ cells (Supplementary Fig. 10f).