In a related model, based on the injection of pancreatic ductal adenocarcinoma cells derived from LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre;R26-LSL-tdTomato mice (KPCT), we observed histomorphology more similar to that of human metastases (Supplementary Fig. 10e). Here, PDX1 is linked to pancreatic ductal adenocarcinoma.