Multiplex-IF of intrahepatic cholangiocarcinoma (Supplementary Fig. 7g) revealed stromal protein gradients similar to those observed in CRLM, which were characterized by ASMA, NGFR, and PDGFRa at the outer edge, and FAP and PDGFRb at the inner side of the rim (Fig. 5e). The gene discussed is PDGFRA; the disease is intrahepatic cholangiocarcinoma.