Because Po, Le, F-Le and Cl-Le are effective in MM cell lines (Fig. 3d and Supplementary Fig. 11a), it is predicted that Po-P, Le-P, F-P and Cl-P showed stronger anti-proliferative effects than F3C-P due to the dual protein degradation of IKZF1/IKZF3 and BET proteins (Fig. 7a). Here, DNER is linked to Miyoshi myopathy.