Furthermore, in the pluripotent human embryonal carcinoma cell line NTERA-2 and colon cancer cell line HCT116, F-P, Cl-P, and F3C-P induced degradation of BET proteins in the same dose range as that of Le-P (Fig. 7d and Supplementary Fig. 11c). Here, DNER is linked to malignant colon neoplasm.