Outgoing signaling patterns upregulated in LE-LE signaling, relative to TC-TC signaling, included Collagen, Laminin, Tenascin, FN1, MIF, APP, CD99, Notch, and CSPG4 pathways (Supplementary Fig. 3f), reinforcing the role of these pathways in facilitating cancer invasion and metastasis. This evidence concerns the gene APP and cancer.