CSPG4 and cancer: Outgoing signaling patterns upregulated in LE-LE signaling, relative to TC-TC signaling, included Collagen, Laminin, Tenascin, FN1, MIF, APP, CD99, Notch, and CSPG4 pathways (Supplementary Fig. 3f), reinforcing the role of these pathways in facilitating cancer invasion and metastasis.