Outgoing signaling patterns upregulated in LE-LE signaling, relative to TC-TC signaling, included Collagen, Laminin, Tenascin, FN1, MIF, APP, CD99, Notch, and CSPG4 pathways (Supplementary Fig. 3f), reinforcing the role of these pathways in facilitating cancer invasion and metastasis. The gene discussed is FN1; the disease is cancer.