Furthermore, consistent with our findings, GSEA analysis revealed that OXPHOS-, fatty acid metabolism-, and folate metabolism-related genes are preferentially enriched in HCC with higher expression of ALDH1L1. In the clinic, AICAr is utilized for tumors such as B cell chronic lymphocytic leukemia, mantle cell lymphoma, hematological cancers, and cervical cancer38. This evidence concerns the gene ALDH1L1 and B-cell chronic lymphocytic leukemia.