Hhat catalyzes the completion of palmitoylation of HH proteins to maintain their stability and normal activity.381 Inhibitors targeting Hhat may therefore block HH protein-mediated pathway activation. Current inhibitor targeting Hhat was RU-SKI 43. Petrova et al. carried out a high throughput screen using a peptide-based assay and identified Hhat specific inhibition by RU-SKI 43  both intracellularly and in vitro.382 They further investigated the potential effect of RU-SKI 43 in cancer. This evidence concerns the gene HHAT and cancer.