Loss of primary cilia might be related to HH signaling pathway inactivation and upregulated RAS/MAPK pathway in resistant BCCs.333 A lower cilia count in the primary lesion might be correlated with BCC recurrence according to a preliminary study.334 Whitson et al. reported non-canonical hedgehog pathway activation also drives drug resistance of Smo inhibitor in BCC.335. Here, SMO is linked to skin basal cell carcinoma.