SMO and B-cell chronic lymphocytic leukemia: Both cyclopamine and 5E1 could inhibit chronic lymphocytic leukemia (CLL) cells in B-CLL patients.390 Stromal cells could induce activation of the paracrine pathway and activated ERK directly via Ptch1 receptor in CLL cells without Smo.390 In this case, cyclopamine treatment was suboptimal, while 5E1 could completely eliminate ERK phosphorylation.390