It has the following features: inhibits HH signaling pathway in a concentration dependent manner; does not show inhibitory activity in the absence of Ptch1 receptors; does not compete with cyclopamine.397 Robotnikinin reduced Gli2 mRNA levels in human keratin forming cells and in primary human synthetic skin tissue.397 There is currently lack of other studies revealing the potential application of robotnikinin in the treatment of cancer. Here, GLI2 is linked to cancer.