SHH and gastric cancer: Shh has been found to be overexpressed in resected GC samples compared to that of adjacent normal tissue.364 Specifically, Shh expressing in H pylori positive patients with early GC was noted to be significantly higher than H pylori negative controls.365 The increased expression of Shh and Gli1 was also shown to be significantly correlated with tumor staging and tumor aggressiveness, suggesting a worse overall survival for patients suffering from GC.193,366