The first inhibitors GANT58 and GANT61, which can inhibit Gli protein production, were identified by representative screening in HEK293 cells transiently expressing Gli1 and Gli-dependent luciferase reporter.468 GANT58 and GANT61 have no effect on other cancer signaling pathways (e.g. TNF signaling/-NF-κB, glucocorticoid and MAPK pathways), and therefore they are highly selective for Gli.468 GANTs can inhibit the proliferation of a variety of cancer cells. Here, NFKB1 is linked to cancer.