Moreover, Gli interacts with the promoter of ABCG2 and regulates its expression in gastric cancer stem cells.367 Accordingly, targeting HH signaling pathway may improve GC chemosensitivity.368,369 Koh et al. investigated PDL-1 expression mediated by Gli in gastric cancer organoids, which may relate to immune evasion in GC.370. This evidence concerns the gene ABCG2 and gastric cancer.