SHH and lung adenocarcinoma: Blockade of HH signaling increased sensitivity to EGFR-TKIs in NSCLC cells.302 HH signaling pathway drives lung adenocarcinoma (LAC) cells growth under stress conditions such as serum-starvation.303 Moreover, microRNA (miRNA) disorders might be related to cell cisplatin resistance in LAC through targeting Gli2.304 Besides, researchers found that Shh+ NSCLC cells produced full-length Shh protein on the membranes of these cells.