Itraconazole is a drug to treat systemic fungal infection, especially in patients with low immune function and cancer.454 In 2010, it was found that itraconazole could inhibit HH signaling pathway by preventing the accumulation of Smo in primary cilia.455 The unique mechanism of action makes itraconazole a feasible choice for the treatment of other HH signaling pathway inhibitors resistance (such as vismodegib). Here, SMO is linked to cancer.