For instance, rs2124440-A is associated with properties of monocytes (MO-SFL-DW, additive allelic effect size = 0.048 SD, unadjusted P-value = 3.4 × 10−11; MO-SFL additive allelic effect size = −0.034 SD, unadjusted P-value = 2.0 × 10−6) and these associations colocalised with lower expression of ITGA4 in monocytes (CD14, PP = 99.7%) and higher inflammatory bowel disease (IBD) risk (PP = 98.2%). This evidence concerns the gene ITGA4 and inflammatory bowel disease.