ITGA4 and inflammatory bowel disease: We have shown more generally how genetic associations with the new traits can be used to interpret colocalizing associations with disease risks and provide evidence to support drug targets, through examples which are corroborated by existing evidence in the literature, including the role of lymphocyte activation in IL-7R/IL-7 mediated risk of MS and the role monocytes ITGA4 mediated risk of inflammatory bowel disease.