Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3, also called vacuolar protein-sorting 34, VPS34) is essential for autophagosome formation, and forms functional complexes with other molecules, like Beclin-1, providing a platform for DFCP1 and WIPI2 to play an essential role in tumor development [6]. This evidence concerns the gene PIK3C3 and neoplasm.