Along with the experimental findings showing the protection of suppression of TH signaling in mouse models of retinal degeneration and the clinical findings showing the link between high serum TH levels/hyperthyroidism and increased incidence of AMD, the present work supports the view that inhibition of TH signaling might be a valuable strategy for photoreceptor protection in retinal degeneration. The gene discussed is TH; the disease is hyperthyroidism.