In contrast to previous studies utilising gene panels or exome sequencing, we did not see clear predominance of a small number of genes (eg, KCNQ2, PRRT2, and SCN1A).4, 7, 22 This finding might reflect that previous studies using gene panels were limited to analysing specific subsets of genes or were conducted before the associations of other genes with epilepsy were identified. This evidence concerns the gene SCN1A and epilepsy.