Given that neurexin 1α is implicated in several neurodevelopmental disorders such as autism spectrum disorder and schizophrenia (33, 34), the aberrant interaction between PCDH15 isoforms and neurexin 1α might serve as a potential pathological mechanism underlying the impact of PCDH15 mutations associated with neurological diseases on neuronal functions. This evidence concerns the gene PCDH15 and autism spectrum disorder.