Pharmacologic inhibition of Ppm1d using GSK2830371 alone did not impair leukemia cell growth, but GSK2830371 synergized with daunorubicin, cytarabine, decitabine, azacitidine, and radiation to kill both Ppm1dT476∗-fl/+ and Ppm1d+/+ cells but not Ppm1d knockout cells (Figure 4D-E; supplemental Figure 4B).16 The gene discussed is PPM1D; the disease is leukemia.