The American Heart Association/American Stroke Association (AHA/ASA) recommend tranexamic acid (TXA) or aminocaproic acid, as well as cryoprecipitate, for treatment of intracranial bleeding after tPA administration.13 The AHA/ASA guidelines do not make specific recommendations for other sources of bleeding; however, given that the recommendations are specific to the mechanism of tPA, they should be followed for any severe or symptomatic bleeding. Here, PLAT is linked to Stroke.