124 Moreover, inhibition of oestrogen synthesis by the aromatase inhibitor anastrozole alleviated experimental PAH in a SuHx rat model by restoring BMPR2 expression.126 Conversely, in the right ventricle of multiple PH rat models and cultured rat right ventricle cardiomyocytes, E2-ERα signalling increased BMPR2 expression.110 Further, basal BMPR2 levels were higher in female right ventricle samples compared to males. Here, BMPR2 is linked to pulmonary arterial hypertension.