BMPR2 and pulmonary arterial hypertension: In this regard, pregnancy has been associated with increased risk of PAH development in BMPR2 mutation carriers, as patients have been diagnosed with PAH after pregnancy.186 Disease severity is also higher peri- and post-partum,187 resulting in a mortality of pregnant PAH patients of around 11–25%.2 These observations can easily be linked to drastic haemodynamic changes during pregnancy,187 but the long-term effects of hormonal changes are often not considered.