Activation of SYK, which is initiated by TREM2-ligand interactions, has recently been shown to be required for STING-mediated IFN induction by HSV1 in different cell lines (31) and also to drive signal transducer and activator of transcription 1 (STAT1) activation in response to infection with RNA viruses (40). The gene discussed is IFNA1; the disease is infection.