We have comprehensively analyzed the results of 14 studies through present meta-analysis and found increased risk of OSA in those with TNF-α-308A allele, which may be explained by elevated TNF-α expression via regulating the promoter transcriptional activity [12].Moreover,TNF-α gene lies in the highly polymorphic major histocompatibility complex (MHC) region. The gene discussed is TNF; the disease is obstructive sleep apnea syndrome.