Prolonged ventilator need was observed in nearly half (48.7%) of the patients, which was found to be associated with various factors such as female gender, inferior wall MI with RV infarct, sub-optimal (<III) TIMI, culprit left main (LM)/right coronary artery (RCA), diabetes, obesity, RV dysfunction, biventricular failure, elevated LVEDP, high admission SOFA score, PCT, CRP, positive balance, negative balance, and frailty status at admission. The gene discussed is CRP; the disease is diabetes mellitus.