Among those, 14 CpGs in two hypomethylated iDMRs were aberrantly methylated in at least two patients with BWS-MLID; PPIEL locus (chromosome 1: 39559298 to 39559744) with a methylation difference of 0.24 and 4 significant probes, and FAM50B locus (chromosome 6: 3849096 to 3849469) with a methylation difference of 0.26 and 10 significant probes. The gene discussed is PPIEL; the disease is Beckwith-Wiedemann syndrome.