By downloading the data of cervical cancer RNA-Seq from TCGA database and using the ESTIMATE calculation tool [13], we first observed the set of genes negatively correlated with immune cell infiltration in patients with different groups of immune cell infiltration, and according to the survival analysis and protein expression in cervical cancer patient samples, MLK4 may be used as a molecular marker related to cervical cancer immune infiltration. The gene discussed is MAP3K21; the disease is cervical cancer.