While there are many genetic epilepsy syndromes linked to mutations in other ion channel genes (reviewed in Nicita et al. (2012), Lerche et al. (2013) and Zimmern et al. (2022)), only case reports were found regarding metabolism, and only a sufficient number of studies warranting discussion were available for epilepsies linked to mutations in SCN1A and KCNA1 at this time. The gene discussed is SCN1A; the disease is epilepsy.