While there are still little data about impairments of brain metabolism, the studies revealed ketogenic diets to be mostly effective, particularly for Dravet syndrome with identified SCN1A mutations as well as mouse and zebrafish models with SCN1A and KCNA1 mutations. This evidence concerns the gene KCNA1 and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.