Loss of function SCN1A mutations are associated with a broad spectrum of phenotypes in people that vary in severity, from ‘just’ febrile seizures, or epilepsy with febrile seizures plus (GEFS+), which are both relatively milder, to Dravet syndrome, the most severe (Catterall et al., 2010; Mantegazza & Broccoli, 2019). The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.