Thus, mouse models lacking functional Scn1a, and zebrafish models lacking the orthologous gene scn1Lab, are usually described as models of Dravet syndrome (as we have done so here for simplicity), but findings in these models may also apply to patients with SCN1A‐associated febrile seizures and GEFS+. This evidence concerns the gene SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.