Tau proteins are predominantly located in the axons of mature neurons, contributing to microtubule stabilization and axonal transport, as well as synaptic plasticity and neuronal excitability.[11] In AD, neurons lose their tau polarization, leading to tau accumulation in the soma and dendrites.[12] Pathologic forms of tau detached from microtubules are transported to somatodendritic compartments through the axon initial segment (AIS) located near the hillock of axons with 20–60 μm length. The gene discussed is MAPT; the disease is Alzheimer disease.