MAPT and Alzheimer disease: These data indicated that the AIS plasticity was severely impaired by tau‐AC, providing a possible explanation for neuronal network hyperexcitability and excitotoxicity observed in various AD mouse models.[26] To further elucidate the molecular mechanism involving tau‐AC and AIS structural plasticity, we treated the neurons with a low dose (1 nm) of the microtubule‐stabilizing agent paclitaxel for 3 h.