Since interstitial cystitis/bladder pain syndrome (IC/BPS) is an inflammatory disease [23], and the method of IC/BPS modeling through cyclophosphamide (CYP) has been verified in many studies [24, 25], we investigated whether serpina3/serpina3n plays a role in the progression of CYP-induced IC/BPS. Here, PPIG is linked to interstitial cystitis.