P2RX7 and early-onset autosomal dominant Alzheimer disease: Yihan revealed that the expression of cell-surface P2X7 receptors is decreased on peripheral blood leukocytes in subjects positive for beta-amyloid plaques with either cognitive impairment or dementia, providing new insights into the role of P2X7 receptors in Alzheimer’s disease and its potential as a biomarker in this disorder.