This presentation included his early studies on the P2X7 receptor in chronic lymphocytic leukaemia lymphocytes, including the discovery that activation of the P2X7 receptor mediates the rapid shedding of L-selectin (CD62L) from these cells and that the P2X7 receptor is inhibited by KN-62, commonly used to study P2X7 receptor signalling. Here, P2RX7 is linked to B-cell chronic lymphocytic leukemia.