APOE and Alzheimer disease: Although the underlying mechanism was not further explored in the present study, we observed the age‐dependent decrease of Ac‐CoA in the hippocampus of the elderly ApoE4 mice and our previous study has demonstrated that GTA treatment can improve hippocampal plasticity in AD mice by increasing histone acetylation (H3K9 and H4K12) (Lin et al., 2023).