Fasting insulin resistance, assessed as HOMA2_IR, reflecting insulin control of hepatic glucose output, decreased from 2.02 (1.44–3.30) to 1.32 (0.97–1.97) at CEP (P=0.001) and to 0.88 (0.51–1.36) at 12 months (P=0.001) when it did not differ significantly from the control group (0.67 [0.47–1.10], P=0.342). Here, INS is linked to Insulin resistance.