Specifically, genes such as CDK1, CCNB1, and CDC20 have shown increased expression and are significantly associated with a negative prognosis in patients.48,49 CDK1 reduction was discovered by Yang et al. to have a significant effect on the suppression of GBM proliferation, and the study suggested that CDK1 is involved in the Akt signaling pathway.16,50 Additional research is warranted to further understand the identification and management of GBM, and the mechanisms underlying GBM are providing valuable insights.51 This evidence concerns the gene CCNB1 and glioblastoma.