Genes that are expressed at moderate levels in the absence of MYC are significantly upregulated in the presence of MYC, while genes expressed at low levels in the absence of MYC show only minor enhancement in its presence.23 In GBM, MYC plays a crucial role in enhancing the self-renewal capability of neurosurgeons and maintaining the tumorigenicity of these cells. This evidence concerns the gene MYC and glioblastoma.