Moreover, supplementation of IL-1β just after BD induction in donors did not affect plasma levels at 6 h since BD, as IL-1β in plasma samples from experimental groups where it was technically possible to obtain them (Sham, BD, BD+IL-6+IL-1, and BD+IL-10-IL-1) was unchanged in all groups (at Sham levels, data not shown). This evidence concerns the gene IL6 and Behcet disease.