High risk patients, who were scheduled for early low-dose DLI, had a considerably higher risk of GvHD compared to non-high risk patients with HRs ranging between 6.3 (CD8 model, 95%-CI 2.1-18.8) and 7.3 (CD4 model, 95%-CI 2.4-22.2), indicating an alloimmune effect of the early low-dose DLI in this setting. Here, CD4 is linked to graft versus host disease.