HLA-G and melanoma: Correspondingly, it was reported that human NK cells that capture HLA-G (a non-classical MHC-I immunosuppressive molecule) from melanoma solid tumor cells not only massively reduce their proliferation and their cytotoxicity, but also are able to suppress the cytotoxic function of other bystander NK cells expressing the HLA-G ligand and inhibitory receptor ILT2 (14).