However, this might not be the case for tumor receptors like HER2, because similarly to our present results, it has been observed that NK cells co-cultured with trastuzumab-opsonized HER2+ breast cancer cells can acquire HER2 receptor via trogocytosis and exhibit higher expression of CD107a than non-HER2-trogocytosed NK cells (47). The gene discussed is ERBB2; the disease is breast cancer.