The alternative splicing of variable exons of CD44 results in variants, which are denoted as CD44v, and the isoform with no variable exon in the mRNA as the standard isoform, CD44s.9In this study, we analyzed the expression patterns of theCD44gene and its association with demographic features, clinicopathological characteristics, and overall survival of patients with HNSCC byin-silicoanalysis. This evidence concerns the gene CD44 and head and neck squamous cell carcinoma.