Upregulation of CD44 in HNSCC has been associated with increased loco-regional recurrence, metastasis, invasion, decreased overall survival, and increased resistance to radiotherapy.7We studied the significance of the CD44 gene and protein expression in HNSCC by using the Cancer Genome Atlas (TCGA) dataset accessed through the University of Alabama at Birmingham Cancer (UALCAN) portal. Here, CD44 is linked to head and neck squamous cell carcinoma.