Sawant et al reported that serum CD44 concentration was found significantly high in patients with primary oral squamous cell carcinoma (OSCC) (n = 64) as compared with healthy individuals (n = 16;p < 0.001) and also in patients whose disease locally recurred (n = 10) as compared with those did not recur (n = 35;p = 0.0026).19Reategui et al characterized CD44v3 in HNSCC cell lines by reverse transcription polymerase chain reaction. This evidence concerns the gene CD44 and oral cavity squamous cell carcinoma.