A statistically significant overexpression of CD44 was demonstrated in OSCC patients compared with those with leukoplakia and healthy controls.23El-Gendi et al reported that papillary thyroid carcinoma (PTC;n = 30) showed higher CD44v6 expression than follicular thyroid carcinoma (n = 10).24On the contrary, downregulation of the CD44 gene was associated with a poor prognosis of laryngeal carcinoma.25 Here, CD44 is linked to Oral leukoplakia.