Three PRMTs (i.e., PRMT1, PRMT4/CARM1 and PRMT5) have each been shown to control vitamin D3-dependent transcription in osteosarcoma cells via interactions with SRC-1/NCOA1 (Moena et al., 2020b), whereas PRMT5 binds to the SWI/SNF component BRG1/SMARCA4 in different cell types (Seth-Vollenweider et al., 2014). This evidence concerns the gene PRMT1 and osteosarcoma.