In a recent large longitudinal study, researchers found that increased CRP was associated with worse baseline cognitive function in non-demented participants; while among participants with dementia, elevated CRP was associated with slower cognitive decline (Lewis and Knight, 2021), suggesting the impact of CRP on cognition may vary with the disease progression (O’Bryant et al., 2010; Gong et al., 2016; Fernandes et al., 2020). Here, CRP is linked to Mental deterioration.