With these challenges at hand, new and innovative strategies are highly warranted that can address the underlying cellular components of cardiovascular disease to include the pathways of the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1), mammalian forkhead transcription factors (FoxOs), and AMP activated protein kinase (AMPK) (Table 1(Tab. The gene discussed is SIRT1; the disease is cardiovascular disorder.