Silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1) plays a significant role during the onset and progression of cardiovascular disease (Charles et al., 2017;[31] Cui et al., 2017[55]; Kostić et al., 2023[124]; Maiese, 2016[190], 2017[171], 2020[172][182], 2021[181][192]; Ministrini et al., 2021[225]; Piao et al., 2021[249]; Watroba and Szukiewicz, 2021[312]; Yuan et al., 2022[331]) (Table 1(Tab. This evidence concerns the gene SIRT1 and cardiovascular disorder.