GPBAR1 and myocardial infarction: Interestingly, the study discussed in our review showed that DCA (10 mg/kg/d) plays protective roles in the heart at the early stages post-myocardial infarction and improves prognosis, and the effects of DCA were independent of the regulation of expression of its receptor TGR5 but dependent on the activation the TGR5 receptor (Wang et al., 2021).