In HBV-induced HCC, candidate genes of choice are TP53, CTNNB1, and TERT due to the prevalence of high-frequency driver mutations (Li and Mao, 2013; Wang et al., 2013; Totoki et al., 2014; Villanueva and Llovet, 2014; Schulze et al., 2015; Zucman-Rossi et al., 2015; Hirotsu et al., 2016). This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.