Earlier studies have shown the most frequent transversion-type mutations at one nucleotide pair of TP53 codon 249 (c.747G>T, pR249S, AGG→AGT) in HCC patients of HBV aetiology from geographical areas of high dietary aflatoxin B1 exposure (Hollstein et al., 1991; Huang et al., 2016). The gene discussed is TP53; the disease is hepatocellular carcinoma.