Interestingly, analysis of the tissue distribution of CXCR6 associated cell populations indicated that CXCR6+ subsets were strongly enriched in tumor or normal tissue, particularly CD8+CXCR6+ T cells and CXCR6+ NK cells, whereas most CXCR6- subsets exhibited preferential enrichment in the peripheral blood (Figure 10C). This evidence concerns the gene CD8A and neoplasm.