CXCR6 and hepatocellular carcinoma: To further investigate the functional characteristics of highly CXCR6-expressing T cells/NK cells and explore the possible correlation between CXCR6 and cytotoxic markers or immune checkpoints, we first clustered another independent single cell HCC cohort of GSE140228 into six main cell types: T cells, NK cells, B cells, plasma cells, myeloid cells and mast cells (Figures 10A, B).