Furthermore, correlation analysis showed that LTA was highly correlated with B cell markers (CD19, CD79A, BANK1 and MS4A1) and regulatory T cell markers (CD4, FOXP3, CD25 and CD39) in bulk sequencing data of TCGA HCC (P < 0.05; Additional file 1: Figures S6A–L). This evidence concerns the gene CD4 and hepatocellular carcinoma.