Underlining the noncanonical function of TERT in regulating the WNT/β-catenin signaling pathway, Trépo et al. [15] found WNT3A-WNT9A as a susceptibility locus for alcohol-related HCC, suggesting an early role of the WNT/β-catenin signaling pathway in alcohol-related HCC carcinogenesis. The gene discussed is WNT3A; the disease is hepatocellular carcinoma.