AKT1 and xanthoma: To determine mTOR signaling activation in eruptive xanthomas, we performed immunohistochemical staining with antibodies against phosphorylated S6 (Ser240/244), 4E-BP1 (Thr37/46), and Akt (Ser473) in eruptive xanthomas (diagnosed by our dermatology clinic) and healthy skin as a control.