Treatment with the tricyclic antidepressant amitriptyline reduced levels of NLRP3 and caspase-1 in peripheral blood mononuclear cells as well as serum IL-beta and IL-18 levels in individuals with major depressive disorder (MDD) (Alcocer-Gómez et al., 2014). This evidence concerns the gene NLRP3 and major depressive disorder.