While the PSEN2-KO mouse does not harbor a known EOAD PSEN2 gene variant (5, 25–27), clinical PSEN2 variants lead to a biochemical loss of normal function (66) such that PSEN-KO models are relevant to a priori assess the biological consequences of PSEN dysfunction in the setting of evoked secondarily generalized focal seizures. Here, PSEN2 is linked to Seizure.