CTCF and malaria: The human malaria parasite P. falciparum executes complex transcriptional programs and has a sophisticated genome organization considering that it encodes relatively few specific transcription factors and lacks key canonical genome organizing factors such as CTCF and lamins (Batsios et al, 2012; Heger et al, 2012; Ay et al, 2014; Bunnik et al, 2019).