AC007038.1|AC084018.1, ZNF687−AS1|AL354733.3, TMPO−AS1|ATP1B3−AS1, AC132192.2|AC004148.1, LINC01063|AC116914.2, RUSC1−AS1|AC004687.1, LINC00944|AC004687.1, CHKB−DT|AL365330.1, MIR924HG|MIR9−3HG, and AL365330.1|MIR9−3HG in model played negative significant roles, while AL390719.2|AL133243.2, AC096992.2|HOXC−AS1, C5orf66−AS1|KDM4A−AS1, C5orf66−AS1|AP000251.1, AC106820.3|KDM4A−AS1, PTOV1−AS2|SNHG25, PTOV1−AS2|AL132712.1, PTOV1−AS2|LINC00205, AC008735.2|SNHG25, and AL360181.2|AC098487.1 played positive roles in HNSCC patients’ survival. This evidence concerns the gene KDM4A-AS1 and head and neck squamous cell carcinoma.