Unfortunately, immune-related pathways have not been enriched, replaced by nicotine addiction, primary immunodeficiency, linoleic acid metabolism, hematopoietic cell lineage, IL-17 signaling pathway, mineral absorption, staphylococcus aureus infection, drug metabolism-cytochrome P450, estrogen signaling pathway, cell adhesion molecules, and ferroptosis (Fig. S6B). The gene discussed is IL17A; the disease is inborn error of immunity.